Harald Herrmann Selected Research

Desmin

1/2022	The desmin mutation R349P increases contractility and fragility of stem cell-generated muscle micro-tissues.
1/2022	New roles for desmin in the maintenance of muscle homeostasis.
12/2020	Dual Functional States of R406W-Desmin Assembly Complexes Cause Cardiomyopathy With Severe Intercalated Disc Derangement in Humans and in Knock-In Mice.
1/2019	The MyoRobot technology discloses a premature biomechanical decay of skeletal muscle fiber bundles derived from R349P desminopathy mice.
1/2017	αB-crystallin is a sensor for assembly intermediates and for the subunit topology of desmin intermediate filaments.
1/2017	Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice.
1/2016	Mutant desmin substantially perturbs mitochondrial morphology, function and maintenance in skeletal muscle tissue.
2/2015	The toxic effect of R350P mutant desmin in striated muscle of man and mouse.
1/2013	Desminopathies: pathology and mechanisms.
1/2012	Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin.

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Harald Herrmann Research Topics

Disease

17	Muscular Diseases (Myopathy) 01/2022 - 02/2003
14	Neoplasms (Cancer) 01/2020 - 07/2010
11	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/2020 - 03/2011
9	Leukemia 11/2020 - 08/2002
8	Cardiomyopathies (Cardiomyopathy) 01/2022 - 01/2013
6	Laminopathies 07/2015 - 10/2004
5	Myofibrillar Myopathy 01/2017 - 07/2006
4	Pelger-Huet Anomaly 03/2013 - 08/2002
3	Philadelphia Chromosome 01/2017 - 05/2011
3	Cystic Fibrosis (Mucoviscidosis) 01/2017 - 10/2013
3	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 02/2015 - 03/2008
3	Ichthyosis (Xeroderma) 12/2014 - 01/2003
3	Muscular Dystrophies (Muscular Dystrophy) 06/2013 - 10/2005
3	Disease Progression 07/2012 - 03/2011
3	Progeria (Hutchinson Gilford Syndrome) 12/2009 - 03/2007
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 01/2016
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2020 - 10/2020
2	Porphyrias (Porphyria) 01/2019 - 07/2013
2	Premature Aging 07/2015 - 12/2009
2	Pdgfra-Associated Chronic Eosinophilic Leukemia 04/2014 - 01/2012
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 03/2014 - 05/2011
2	Liver Diseases (Liver Disease) 01/2011 - 08/2007
2	Systemic Mastocytosis 09/2010 - 06/2010
2	Cataract (Cataracts) 03/2009 - 11/2008
1	Dysgeusia (Parageusia) 05/2022
1	Deglutition Disorders (Dysphagia) 05/2022
1	Xerostomia 05/2022
1	Squamous Cell Carcinoma of Head and Neck 05/2022
1	Restrictive Cardiomyopathy 12/2020
1	Hepatocellular Carcinoma (Hepatoma) 01/2019
1	End Stage Liver Disease 01/2019
1	Prostatic Neoplasms (Prostate Cancer) 01/2019
1	Carcinoma (Carcinomatosis) 01/2018
1	Breast Neoplasms (Breast Cancer) 01/2018
1	Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara) 09/2017
1	familial dilated cardiomyopathy 01/2016
1	Ataxia (Dyssynergia) 08/2015
1	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 08/2015
1	Cognitive Dysfunction 08/2015
1	Epilepsy (Aura) 08/2015
1	Cardiac Arrhythmias (Arrythmia) 02/2015
1	Colonic Neoplasms (Colon Cancer) 01/2015
1	Hypersensitivity (Allergy) 07/2014
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 07/2014
1	Hemorrhage 01/2014

Drug/Important Bio-Agent (IBA)

19	DesminIBA 01/2022 - 02/2003
19	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2006
9	LaminsIBA 08/2015 - 10/2005
8	Lamin Type A (Lamin A)IBA 01/2016 - 10/2004
6	Pharmaceutical PreparationsIBA 01/2020 - 08/2002
5	VimentinIBA 01/2018 - 11/2008
5	Keratins (Keratin)IBA 09/2017 - 01/2006
4	Tyrosine Kinase InhibitorsIBA 01/2019 - 01/2012
4	Oncogene Proteins (Oncogene Protein)IBA 01/2017 - 07/2012
4	ChromatinIBA 12/2014 - 08/2002
4	Imatinib Mesylate (Gleevec)FDA Link 04/2014 - 09/2010
4	Lamin B ReceptorIBA 03/2013 - 08/2002
4	HeterochromatinIBA 11/2010 - 08/2002
3	Protein AggregatesIBA 01/2022 - 11/2008
3	NucleotidesIBA 01/2017 - 10/2013
3	Messenger RNA (mRNA)IBA 03/2014 - 03/2008
2	AntigensIBA 10/2020 - 04/2007
2	nilotinib FDA Link 01/2018 - 01/2012
2	Biological ProductsIBA 01/2018 - 07/2010
2	lamin CIBA 01/2016 - 07/2015
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 03/2014 - 11/2008
2	CytokinesIBA 02/2012 - 06/2010
2	UbiquitinIBA 01/2012 - 11/2008
2	K-18 conjugate (K18)IBA 01/2011 - 08/2007
1	Heme (Haem)IBA 01/2019
1	Deferoxamine (Desferal)FDA LinkGeneric 01/2019
1	protoporphyrin IXIBA 01/2019
1	3,5- diethoxycarbonyl- 1,4- dihydrocollidineIBA 01/2019
1	PorphyrinsIBA 01/2019
1	Aminolevulinic Acid (Levulan)FDA Link 01/2019
1	Simvastatin (Zocor)FDA LinkGeneric 01/2018
1	VildagliptinIBA 01/2018
1	Crystallins (Crystallin)IBA 01/2017
1	Small Heat-Shock ProteinsIBA 01/2017
1	Phenylalanine (L-Phenylalanine)FDA Link 01/2017
1	Drug CombinationsIBA 01/2017
1	Keratin-8 (Keratin 8)IBA 01/2017
1	Cyclic AMP (AMP, Cyclic)IBA 07/2016
1	Phospholipases A2 (Phospholipase A2)IBA 07/2016
1	LigandsIBA 07/2016
1	Chloride Channels (Chloride Channel)IBA 07/2016
1	Anticonvulsants (Antiepileptic Drugs)IBA 08/2015
1	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 01/2015
1	AC133 AntigenIBA 01/2015
1	Immunoglobulin E (IgE)IBA 07/2014
1	Alemtuzumab (Campath)FDA Link 07/2014
1	Heme Oxygenase-1IBA 03/2014

Therapy/Procedure

7	Therapeutics 08/2019 - 03/2009
2	Radiotherapy 05/2022 - 01/2019
1	Free Tissue Flaps 05/2022
1	Heart Transplantation (Grafting, Heart) 12/2020
1	Drug Therapy (Chemotherapy) 11/2020
1	Immunotherapy 11/2020
1	Image-Guided Radiotherapy 01/2019
1	Brachytherapy 01/2019